{"data":{"id":3613,"citation":"Kettle JG, Bagal SK, Bickerton S, Bodnarchuk MS, Breed J, Carbajo RJ, Cassar DJ, Chakraborty A, Cosulich S, Cumming I, Davies M, Eatherton A, Evans L, Feron L, Fillery S, Gleave ES, Goldberg FW, Harlfinger S, Hanson L, Howard M, Howells R, Jackson A, Kemmitt P, Kingston JK, Lamont S, Lewis HJ, Li S, Liu L, Ogg D, Phillips C, Polanski R, Robb G, Robinson D, Ross S, Smith JM, Tonge M, Whiteley R, Yang J, Zhang L, Zhao X.: Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRAS<sup>G12C<\/sup>. J Med Chem, Volume 63 (9), 2020","title":"Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRAS<sup>G12C<\/sup>.","doi":"10.1021\/acs.jmedchem.9b01720","doi_url":"https:\/\/doi.org\/10.1021\/acs.jmedchem.9b01720","pmid":"32023060","pmid_url":"https:\/\/pubmed.ncbi.nlm.nih.gov\/32023060\/","year":2020,"journal":"J Med Chem","volume":"63","issue":"9","page":"4468-4483","authors":[{"first_name":"Bagal SK","last_name":null,"full_name":null},{"first_name":"Bickerton S","last_name":null,"full_name":null},{"first_name":"Bodnarchuk MS","last_name":null,"full_name":null},{"first_name":"Breed J","last_name":null,"full_name":null},{"first_name":"Carbajo RJ","last_name":null,"full_name":null},{"first_name":"Cassar DJ","last_name":null,"full_name":null},{"first_name":"Chakraborty A","last_name":null,"full_name":null},{"first_name":"Cosulich S","last_name":null,"full_name":null},{"first_name":"Cumming I","last_name":null,"full_name":null},{"first_name":"Davies M","last_name":null,"full_name":null},{"first_name":"Eatherton A","last_name":null,"full_name":null},{"first_name":"Evans L","last_name":null,"full_name":null},{"first_name":"Feron L","last_name":null,"full_name":null},{"first_name":"Fillery S","last_name":null,"full_name":null},{"first_name":"Gleave ES","last_name":null,"full_name":null},{"first_name":"Goldberg FW","last_name":null,"full_name":null},{"first_name":"Hanson L","last_name":null,"full_name":null},{"first_name":"Harlfinger S","last_name":null,"full_name":null},{"first_name":"Howard M","last_name":null,"full_name":null},{"first_name":"Howells R","last_name":null,"full_name":null},{"first_name":"Jackson A","last_name":null,"full_name":null},{"first_name":"Kemmitt P","last_name":null,"full_name":null},{"first_name":"Kettle JG","last_name":null,"full_name":null},{"first_name":"Kingston JK","last_name":null,"full_name":null},{"first_name":"Lamont S","last_name":null,"full_name":null},{"first_name":"Lewis HJ","last_name":null,"full_name":null},{"first_name":"Li S","last_name":null,"full_name":null},{"first_name":"Liu L","last_name":null,"full_name":null},{"first_name":"Ogg D","last_name":null,"full_name":null},{"first_name":"Phillips C","last_name":null,"full_name":null},{"first_name":"Polanski R","last_name":null,"full_name":null},{"first_name":"Robb G","last_name":null,"full_name":null},{"first_name":"Robinson D","last_name":null,"full_name":null},{"first_name":"Ross S","last_name":null,"full_name":null},{"first_name":"Smith JM","last_name":null,"full_name":null},{"first_name":"Tonge M","last_name":null,"full_name":null},{"first_name":"Whiteley R","last_name":null,"full_name":null},{"first_name":"Yang J","last_name":null,"full_name":null},{"first_name":"Zhang L","last_name":null,"full_name":null},{"first_name":"Zhao X.","last_name":null,"full_name":null}],"url":"https:\/\/molmedb.upol.cz\/api\/v1\/publications\/3613","landing_page":"https:\/\/molmedb.upol.cz\/publication\/3613","created_at":"2024-05-21T20:12:42.000000Z","updated_at":null}}