{"data":{"id":3430,"citation":"Barlaam B, Cosulich S, Degorce S, Fitzek M, Green S, Hancox U, Lambert-van der Brempt C, Lohmann JJ, Maudet M, Morgentin R, Pasquet MJ, P\u00e9ru A, Pl\u00e9 P, Saleh T, Vautier M, Walker M, Ward L, Warin N.: Discovery of (R)-8-(1-(3,5-difluorophenylamino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide (AZD8186): a potent and selective inhibitor of PI3K\u03b2 and PI3K\u03b4 for the treatment of PTEN-deficient cancers. J Med Chem, Volume 58 (2), 2015","title":"Discovery of (R)-8-(1-(3,5-difluorophenylamino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide (AZD8186): a potent and selective inhibitor of PI3K\u03b2 and PI3K\u03b4 for the treatment of PTEN-deficient cancers.","doi":"10.1021\/jm501629p","doi_url":"https:\/\/doi.org\/10.1021\/jm501629p","pmid":"25514658","pmid_url":"https:\/\/pubmed.ncbi.nlm.nih.gov\/25514658\/","year":2015,"journal":"J Med Chem","volume":"58","issue":"2","page":"943-962","authors":[{"first_name":"Barlaam B","last_name":null,"full_name":null},{"first_name":"Cosulich S","last_name":null,"full_name":null},{"first_name":"Degorce S","last_name":null,"full_name":null},{"first_name":"Fitzek M","last_name":null,"full_name":null},{"first_name":"Green S","last_name":null,"full_name":null},{"first_name":"Hancox U","last_name":null,"full_name":null},{"first_name":"Lambert-van der Brempt C","last_name":null,"full_name":null},{"first_name":"Lohmann JJ","last_name":null,"full_name":null},{"first_name":"Maudet M","last_name":null,"full_name":null},{"first_name":"Morgentin R","last_name":null,"full_name":null},{"first_name":"Pasquet MJ","last_name":null,"full_name":null},{"first_name":"P\u00e9ru A","last_name":null,"full_name":null},{"first_name":"Pl\u00e9 P","last_name":null,"full_name":null},{"first_name":"Saleh T","last_name":null,"full_name":null},{"first_name":"Vautier M","last_name":null,"full_name":null},{"first_name":"Walker M","last_name":null,"full_name":null},{"first_name":"Ward L","last_name":null,"full_name":null},{"first_name":"Warin N.","last_name":null,"full_name":null}],"url":"https:\/\/molmedb.upol.cz\/api\/v1\/publications\/3430","landing_page":"https:\/\/molmedb.upol.cz\/publication\/3430","created_at":"2024-05-21T20:12:03.000000Z","updated_at":null}}