{"data":{"id":3249,"citation":"Blake JF, Burkard M, Chan J, Chen H, Chou KJ, Diaz D, Dudley DA, Gaudino JJ, Gould SE, Grina J, Hunsaker T, Liu L, Martinson M, Moreno D, Mueller L, Orr C, Pacheco P, Qin A, Rasor K, Ren L, Robarge K, Shahidi-Latham S, Stults J, Sullivan F, Wang W, Yin J, Zhou A, Belvin M, Merchant M, Moffat J, Schwarz JB.: Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1\/2 (ERK1\/2) Inhibitor in Early Clinical Development. J Med Chem, Volume 59 (12), 2016","title":"Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1\/2 (ERK1\/2) Inhibitor in Early Clinical Development.","doi":"10.1021\/acs.jmedchem.6b00389","doi_url":"https:\/\/doi.org\/10.1021\/acs.jmedchem.6b00389","pmid":"27227380","pmid_url":"https:\/\/pubmed.ncbi.nlm.nih.gov\/27227380\/","year":2016,"journal":"J Med Chem","volume":"59","issue":"12","page":"5650-5660","authors":[{"first_name":"Belvin M","last_name":null,"full_name":null},{"first_name":"Blake JF","last_name":null,"full_name":null},{"first_name":"Burkard M","last_name":null,"full_name":null},{"first_name":"Chan J","last_name":null,"full_name":null},{"first_name":"Chen H","last_name":null,"full_name":null},{"first_name":"Chou KJ","last_name":null,"full_name":null},{"first_name":"Diaz D","last_name":null,"full_name":null},{"first_name":"Dudley DA","last_name":null,"full_name":null},{"first_name":"Gaudino JJ","last_name":null,"full_name":null},{"first_name":"Gould SE","last_name":null,"full_name":null},{"first_name":"Grina J","last_name":null,"full_name":null},{"first_name":"Hunsaker T","last_name":null,"full_name":null},{"first_name":"Liu L","last_name":null,"full_name":null},{"first_name":"Martinson M","last_name":null,"full_name":null},{"first_name":"Merchant M","last_name":null,"full_name":null},{"first_name":"Moffat J","last_name":null,"full_name":null},{"first_name":"Moreno D","last_name":null,"full_name":null},{"first_name":"Mueller L","last_name":null,"full_name":null},{"first_name":"Orr C","last_name":null,"full_name":null},{"first_name":"Pacheco P","last_name":null,"full_name":null},{"first_name":"Qin A","last_name":null,"full_name":null},{"first_name":"Rasor K","last_name":null,"full_name":null},{"first_name":"Ren L","last_name":null,"full_name":null},{"first_name":"Robarge K","last_name":null,"full_name":null},{"first_name":"Schwarz JB.","last_name":null,"full_name":null},{"first_name":"Shahidi-Latham S","last_name":null,"full_name":null},{"first_name":"Stults J","last_name":null,"full_name":null},{"first_name":"Sullivan F","last_name":null,"full_name":null},{"first_name":"Wang W","last_name":null,"full_name":null},{"first_name":"Yin J","last_name":null,"full_name":null},{"first_name":"Zhou A","last_name":null,"full_name":null}],"url":"https:\/\/molmedb.upol.cz\/api\/v1\/publications\/3249","landing_page":"https:\/\/molmedb.upol.cz\/publication\/3249","created_at":"2024-05-21T09:16:32.000000Z","updated_at":null}}