{"data":{"id":3206,"citation":"Zak M, Mendonca R, Balazs M, Barrett K, Bergeron P, Blair WS, Chang C, Deshmukh G, Devoss J, Dragovich PS, Eigenbrot C, Ghilardi N, Gibbons P, Gradl S, Hamman C, Hanan EJ, Harstad E, Hewitt PR, Hurley CA, Jin T, Johnson A, Johnson T, Kenny JR, Koehler MF, Bir Kohli P, Kulagowski JJ, Labadie S, Liao J, Liimatta M, Lin Z, Lupardus PJ, Maxey RJ, Murray JM, Pulk R, Rodriguez M, Savage S, Shia S, Steffek M, Ubhayakar S, Ultsch M, van Abbema A, Ward SI, Xiao L, Xiao Y.: Discovery and optimization of C-2 methyl imidazopyrrolopyridines as potent and orally bioavailable JAK1 inhibitors with selectivity over JAK2. J Med Chem, Volume 55 (13), 2012","title":"Discovery and optimization of C-2 methyl imidazopyrrolopyridines as potent and orally bioavailable JAK1 inhibitors with selectivity over JAK2.","doi":"10.1021\/jm300628c","doi_url":"https:\/\/doi.org\/10.1021\/jm300628c","pmid":"22698084","pmid_url":"https:\/\/pubmed.ncbi.nlm.nih.gov\/22698084\/","year":2012,"journal":"J Med Chem","volume":"55","issue":"13","page":"6176-6193","authors":[{"first_name":"Balazs M","last_name":null,"full_name":null},{"first_name":"Barrett K","last_name":null,"full_name":null},{"first_name":"Bergeron P","last_name":null,"full_name":null},{"first_name":"Bir Kohli P","last_name":null,"full_name":null},{"first_name":"Blair WS","last_name":null,"full_name":null},{"first_name":"Chang C","last_name":null,"full_name":null},{"first_name":"Deshmukh G","last_name":null,"full_name":null},{"first_name":"DeVoss J","last_name":null,"full_name":null},{"first_name":"Dragovich PS","last_name":null,"full_name":null},{"first_name":"Eigenbrot C","last_name":null,"full_name":null},{"first_name":"Ghilardi N","last_name":null,"full_name":null},{"first_name":"Gibbons P","last_name":null,"full_name":null},{"first_name":"Gradl S","last_name":null,"full_name":null},{"first_name":"Hamman C","last_name":null,"full_name":null},{"first_name":"Hanan EJ","last_name":null,"full_name":null},{"first_name":"Harstad E","last_name":null,"full_name":null},{"first_name":"Hewitt PR","last_name":null,"full_name":null},{"first_name":"Hurley CA","last_name":null,"full_name":null},{"first_name":"Jin T","last_name":null,"full_name":null},{"first_name":"Johnson A","last_name":null,"full_name":null},{"first_name":"Johnson T","last_name":null,"full_name":null},{"first_name":"Kenny JR","last_name":null,"full_name":null},{"first_name":"Koehler MF","last_name":null,"full_name":null},{"first_name":"Kulagowski JJ","last_name":null,"full_name":null},{"first_name":"Labadie S","last_name":null,"full_name":null},{"first_name":"Liao J","last_name":null,"full_name":null},{"first_name":"Liimatta M","last_name":null,"full_name":null},{"first_name":"Lin Z","last_name":null,"full_name":null},{"first_name":"Lupardus PJ","last_name":null,"full_name":null},{"first_name":"Maxey RJ","last_name":null,"full_name":null},{"first_name":"Mendonca R","last_name":null,"full_name":null},{"first_name":"Murray JM","last_name":null,"full_name":null},{"first_name":"Pulk R","last_name":null,"full_name":null},{"first_name":"Rodriguez M","last_name":null,"full_name":null},{"first_name":"Savage S","last_name":null,"full_name":null},{"first_name":"Shia S","last_name":null,"full_name":null},{"first_name":"Steffek M","last_name":null,"full_name":null},{"first_name":"Ubhayakar S","last_name":null,"full_name":null},{"first_name":"Ultsch M","last_name":null,"full_name":null},{"first_name":"van Abbema A","last_name":null,"full_name":null},{"first_name":"Ward SI","last_name":null,"full_name":null},{"first_name":"Xiao L","last_name":null,"full_name":null},{"first_name":"Xiao Y.","last_name":null,"full_name":null},{"first_name":"Zak M","last_name":null,"full_name":null}],"url":"https:\/\/molmedb.upol.cz\/api\/v1\/publications\/3206","landing_page":"https:\/\/molmedb.upol.cz\/publication\/3206","created_at":"2024-05-21T09:16:21.000000Z","updated_at":null}}