{"data":{"id":3170,"citation":"Brodney MA, Barreiro G, Ogilvie K, Hajos-Korcsok E, Murray J, Vajdos F, Ambroise C, Christoffersen C, Fisher K, Lanyon L, Liu J, Nolan CE, Withka JM, Borzilleri KA, Efremov I, Oborski CE, Varghese A, O'Neill BT.: Spirocyclic sulfamides as \u03b2-secretase 1 (BACE-1) inhibitors for the treatment of Alzheimer's disease: utilization of structure based drug design, WaterMap, and CNS penetration studies to identify centrally efficacious inhibitors. J Med Chem, Volume 55 (21), 2012","title":"Spirocyclic sulfamides as \u03b2-secretase 1 (BACE-1) inhibitors for the treatment of Alzheimer's disease: utilization of structure based drug design, WaterMap, and CNS penetration studies to identify centrally efficacious inhibitors.","doi":"10.1021\/jm3009426","doi_url":"https:\/\/doi.org\/10.1021\/jm3009426","pmid":"22984865","pmid_url":"https:\/\/pubmed.ncbi.nlm.nih.gov\/22984865\/","year":2012,"journal":"J Med Chem","volume":"55","issue":"21","page":"9224-9239","authors":[{"first_name":"Ambroise C","last_name":null,"full_name":null},{"first_name":"Barreiro G","last_name":null,"full_name":null},{"first_name":"Borzilleri KA","last_name":null,"full_name":null},{"first_name":"Brodney MA","last_name":null,"full_name":null},{"first_name":"Christoffersen C","last_name":null,"full_name":null},{"first_name":"Efremov I","last_name":null,"full_name":null},{"first_name":"Fisher K","last_name":null,"full_name":null},{"first_name":"Hajos-Korcsok E","last_name":null,"full_name":null},{"first_name":"Lanyon L","last_name":null,"full_name":null},{"first_name":"Liu J","last_name":null,"full_name":null},{"first_name":"Murray J","last_name":null,"full_name":null},{"first_name":"Nolan CE","last_name":null,"full_name":null},{"first_name":"O'Neill BT.","last_name":null,"full_name":null},{"first_name":"Oborski CE","last_name":null,"full_name":null},{"first_name":"Ogilvie K","last_name":null,"full_name":null},{"first_name":"Vajdos F","last_name":null,"full_name":null},{"first_name":"Varghese A","last_name":null,"full_name":null},{"first_name":"Withka JM","last_name":null,"full_name":null}],"url":"https:\/\/molmedb.upol.cz\/api\/v1\/publications\/3170","landing_page":"https:\/\/molmedb.upol.cz\/publication\/3170","created_at":"2024-05-21T09:16:10.000000Z","updated_at":null}}