{"data":{"id":2713,"citation":"Wang X, Liu B, Searle X, Yeung C, Bogdan A, Greszler S, Singh A, Fan Y, Swensen AM, Vortherms T, Balut C, Jia Y, Desino K, Gao W, Yong H, Tse C, Kym P.: Discovery of 4-[(2R,4R)-4-({[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl}amino)-7-(difluoromethoxy)-3,4-dihydro-2H-chromen-2-yl]benzoic Acid (ABBV\/GLPG-2222), a Potent Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Corrector for the Treatment of Cystic Fibrosis. J Med Chem, Volume 61 (4), 2018","title":"Discovery of 4-[(2R,4R)-4-({[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl}amino)-7-(difluoromethoxy)-3,4-dihydro-2H-chromen-2-yl]benzoic Acid (ABBV\/GLPG-2222), a Potent Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Corrector for the Treatment of Cystic Fibrosis.","doi":"10.1021\/acs.jmedchem.7b01339","doi_url":"https:\/\/doi.org\/10.1021\/acs.jmedchem.7b01339","pmid":"29251932","pmid_url":"https:\/\/pubmed.ncbi.nlm.nih.gov\/29251932\/","year":2018,"journal":"J Med Chem","volume":"61","issue":"4","page":"1436-1449","authors":[{"first_name":"Balut C","last_name":null,"full_name":null},{"first_name":"Bogdan A","last_name":null,"full_name":null},{"first_name":"Desino K","last_name":null,"full_name":null},{"first_name":"Fan Y","last_name":null,"full_name":null},{"first_name":"Gao W","last_name":null,"full_name":null},{"first_name":"Greszler S","last_name":null,"full_name":null},{"first_name":"Jia Y","last_name":null,"full_name":null},{"first_name":"Kym P.","last_name":null,"full_name":null},{"first_name":"Liu B","last_name":null,"full_name":null},{"first_name":"Searle X","last_name":null,"full_name":null},{"first_name":"Singh A","last_name":null,"full_name":null},{"first_name":"Swensen AM","last_name":null,"full_name":null},{"first_name":"Tse C","last_name":null,"full_name":null},{"first_name":"Vortherms T","last_name":null,"full_name":null},{"first_name":"Wang X","last_name":null,"full_name":null},{"first_name":"Yeung C","last_name":null,"full_name":null},{"first_name":"Yong H","last_name":null,"full_name":null}],"url":"https:\/\/molmedb.upol.cz\/api\/v1\/publications\/2713","landing_page":"https:\/\/molmedb.upol.cz\/publication\/2713","created_at":"2023-06-23T15:09:26.000000Z","updated_at":null}}