{"data":{"id":2698,"citation":"Kawada H, Ebiike H, Tsukazaki M, Yamamoto S, Koyama K, Nakamura M, Morikami K, Yoshinari K, Yoshida M, Ogawa K, Shimma N, Tsukuda T, Ohwada J.: Optimization of the phenylurea moiety in a phosphoinositide 3-kinase (PI3K) inhibitor to improve water solubility and the PK profile by introducing a solubilizing group and ortho substituents. Bioorg Med Chem, Volume 24 (13), 2016","title":"Optimization of the phenylurea moiety in a phosphoinositide 3-kinase (PI3K) inhibitor to improve water solubility and the PK profile by introducing a solubilizing group and ortho substituents.","doi":"10.1016\/j.bmc.2016.04.060","doi_url":"https:\/\/doi.org\/10.1016\/j.bmc.2016.04.060","pmid":"27189888","pmid_url":"https:\/\/pubmed.ncbi.nlm.nih.gov\/27189888\/","year":2016,"journal":"Bioorg Med Chem","volume":"24","issue":"13","page":"2897-2906","authors":[{"first_name":"Ebiike H","last_name":null,"full_name":null},{"first_name":"Kawada H","last_name":null,"full_name":null},{"first_name":"Koyama K","last_name":null,"full_name":null},{"first_name":"Morikami K","last_name":null,"full_name":null},{"first_name":"Nakamura M","last_name":null,"full_name":null},{"first_name":"Ogawa K","last_name":null,"full_name":null},{"first_name":"Ohwada J.","last_name":null,"full_name":null},{"first_name":"Shimma N","last_name":null,"full_name":null},{"first_name":"Tsukazaki M","last_name":null,"full_name":null},{"first_name":"Tsukuda T","last_name":null,"full_name":null},{"first_name":"Yamamoto S","last_name":null,"full_name":null},{"first_name":"Yoshida M","last_name":null,"full_name":null},{"first_name":"Yoshinari K","last_name":null,"full_name":null}],"url":"https:\/\/molmedb.upol.cz\/api\/v1\/publications\/2698","landing_page":"https:\/\/molmedb.upol.cz\/publication\/2698","created_at":"2023-06-23T15:09:22.000000Z","updated_at":null}}