{"data":{"id":2208,"citation":"Chen C, Wu D, Guo Z, Xie Q, Reinhart GJ, Madan A, Wen J, Chen T, Huang CQ, Chen M, Chen Y, Tucci FC, Rowbottom M, Pontillo J, Zhu YF, Wade W, Saunders J, Bozigian H, Struthers RS.: Discovery of sodium R-(+)-4-{2-[5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyrate (elagolix), a potent and orally available nonpeptide antagonist of the human gonadotropin-releasing hormone receptor. J Med Chem, Volume 51 (23), 2008","title":"Discovery of sodium R-(+)-4-{2-[5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyrate (elagolix), a potent and orally available nonpeptide antagonist of the human gonadotropin-releasing hormone receptor.","doi":"10.1021\/jm8006454","doi_url":"https:\/\/doi.org\/10.1021\/jm8006454","pmid":"19006286","pmid_url":"https:\/\/pubmed.ncbi.nlm.nih.gov\/19006286\/","year":2008,"journal":"J Med Chem","volume":"51","issue":"23","page":"7478-7485","authors":[{"first_name":"Bozigian H","last_name":null,"full_name":null},{"first_name":"Chen C","last_name":null,"full_name":null},{"first_name":"Chen M","last_name":null,"full_name":null},{"first_name":"Chen T","last_name":null,"full_name":null},{"first_name":"Chen Y","last_name":null,"full_name":null},{"first_name":"Guo Z","last_name":null,"full_name":null},{"first_name":"Huang CQ","last_name":null,"full_name":null},{"first_name":"Madan A","last_name":null,"full_name":null},{"first_name":"Pontillo J","last_name":null,"full_name":null},{"first_name":"Reinhart GJ","last_name":null,"full_name":null},{"first_name":"Rowbottom M","last_name":null,"full_name":null},{"first_name":"Saunders J","last_name":null,"full_name":null},{"first_name":"Struthers RS.","last_name":null,"full_name":null},{"first_name":"Tucci FC","last_name":null,"full_name":null},{"first_name":"Wade W","last_name":null,"full_name":null},{"first_name":"Wen J","last_name":null,"full_name":null},{"first_name":"Wu D","last_name":null,"full_name":null},{"first_name":"Xie Q","last_name":null,"full_name":null},{"first_name":"Zhu YF","last_name":null,"full_name":null}],"url":"https:\/\/molmedb.upol.cz\/api\/v1\/publications\/2208","landing_page":"https:\/\/molmedb.upol.cz\/publication\/2208","created_at":"2023-06-23T10:10:32.000000Z","updated_at":null}}