{"data":{"id":2091,"citation":"Mayer SC, Kreft AF, Harrison B, Abou-Gharbia M, Antane M, Aschmies S, Atchison K, Chlenov M, Cole DC, Comery T, Diamantidis G, Ellingboe J, Fan K, Galante R, Gonzales C, Ho DM, Hoke ME, Hu Y, Huryn D, Jain U, Jin M, Kremer K, Kubrak D, Lin M, Lu P, Magolda R, Martone R, Moore W, Oganesian A, Pangalos MN, Porte A, Reinhart P, Resnick L, Riddell DR, Sonnenberg-Reines J, Stock JR, Sun SC, Wagner E, Wang T, Woller K, Xu Z, Zaleska MM, Zeldis J, Zhang M, Zhou H, Jacobsen JS.: Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease. J Med Chem, Volume 51 (23), 2008","title":"Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease.","doi":"10.1021\/jm801252w","doi_url":"https:\/\/doi.org\/10.1021\/jm801252w","pmid":"19012391","pmid_url":"https:\/\/pubmed.ncbi.nlm.nih.gov\/19012391\/","year":2008,"journal":"J Med Chem","volume":"51","issue":"23","page":"7348-7351","authors":[{"first_name":"Abou-Gharbia M","last_name":null,"full_name":null},{"first_name":"Antane M","last_name":null,"full_name":null},{"first_name":"Aschmies S","last_name":null,"full_name":null},{"first_name":"Atchison K","last_name":null,"full_name":null},{"first_name":"Chlenov M","last_name":null,"full_name":null},{"first_name":"Cole DC","last_name":null,"full_name":null},{"first_name":"Comery T","last_name":null,"full_name":null},{"first_name":"Diamantidis G","last_name":null,"full_name":null},{"first_name":"Ellingboe J","last_name":null,"full_name":null},{"first_name":"Fan K","last_name":null,"full_name":null},{"first_name":"Galante R","last_name":null,"full_name":null},{"first_name":"Gonzales C","last_name":null,"full_name":null},{"first_name":"Harrison B","last_name":null,"full_name":null},{"first_name":"Ho DM","last_name":null,"full_name":null},{"first_name":"Hoke ME","last_name":null,"full_name":null},{"first_name":"Hu Y","last_name":null,"full_name":null},{"first_name":"Huryn D","last_name":null,"full_name":null},{"first_name":"Jacobsen JS.","last_name":null,"full_name":null},{"first_name":"Jain U","last_name":null,"full_name":null},{"first_name":"Jin M","last_name":null,"full_name":null},{"first_name":"Kreft AF","last_name":null,"full_name":null},{"first_name":"Kremer K","last_name":null,"full_name":null},{"first_name":"Kubrak D","last_name":null,"full_name":null},{"first_name":"Lin M","last_name":null,"full_name":null},{"first_name":"Lu P","last_name":null,"full_name":null},{"first_name":"Magolda R","last_name":null,"full_name":null},{"first_name":"Martone R","last_name":null,"full_name":null},{"first_name":"Mayer SC","last_name":null,"full_name":null},{"first_name":"Moore W","last_name":null,"full_name":null},{"first_name":"Oganesian A","last_name":null,"full_name":null},{"first_name":"Pangalos MN","last_name":null,"full_name":null},{"first_name":"Porte A","last_name":null,"full_name":null},{"first_name":"Reinhart P","last_name":null,"full_name":null},{"first_name":"Resnick L","last_name":null,"full_name":null},{"first_name":"Riddell DR","last_name":null,"full_name":null},{"first_name":"Sonnenberg-Reines J","last_name":null,"full_name":null},{"first_name":"Stock JR","last_name":null,"full_name":null},{"first_name":"Sun SC","last_name":null,"full_name":null},{"first_name":"Wagner E","last_name":null,"full_name":null},{"first_name":"Wang T","last_name":null,"full_name":null},{"first_name":"Woller K","last_name":null,"full_name":null},{"first_name":"Xu Z","last_name":null,"full_name":null},{"first_name":"Zaleska MM","last_name":null,"full_name":null},{"first_name":"Zeldis J","last_name":null,"full_name":null},{"first_name":"Zhang M","last_name":null,"full_name":null},{"first_name":"Zhou H","last_name":null,"full_name":null}],"url":"https:\/\/molmedb.upol.cz\/api\/v1\/publications\/2091","landing_page":"https:\/\/molmedb.upol.cz\/publication\/2091","created_at":"2023-06-23T10:10:06.000000Z","updated_at":null}}