{"data":{"id":2067,"citation":"Lu T, Markotan T, Ballentine SK, Giardino EC, Spurlino J, Crysler CS, Brown K, Maryanoff BE, Tomczuk BE, Damiano BP, Shukla U, End D, Andrade-Gordon P, Bone RF, Player MR.: Discovery and clinical evaluation of 1-{N-[2-(amidinoaminooxy)ethyl]amino}carbonylmethyl-6-methyl-3-[2,2-difluoro-2-phenylethylamino]pyrazinone (RWJ-671818), a thrombin inhibitor with an oxyguanidine P1 motif. J Med Chem, Volume 53 (4), 2010","title":"Discovery and clinical evaluation of 1-{N-[2-(amidinoaminooxy)ethyl]amino}carbonylmethyl-6-methyl-3-[2,2-difluoro-2-phenylethylamino]pyrazinone (RWJ-671818), a thrombin inhibitor with an oxyguanidine P1 motif.","doi":"10.1021\/jm901802n","doi_url":"https:\/\/doi.org\/10.1021\/jm901802n","pmid":"20102150","pmid_url":"https:\/\/pubmed.ncbi.nlm.nih.gov\/20102150\/","year":2010,"journal":"J Med Chem","volume":"53","issue":"4","page":"1843-1856","authors":[{"first_name":"Andrade-Gordon P","last_name":null,"full_name":null},{"first_name":"Ballentine SK","last_name":null,"full_name":null},{"first_name":"Bone RF","last_name":null,"full_name":null},{"first_name":"Brown K","last_name":null,"full_name":null},{"first_name":"Crysler CS","last_name":null,"full_name":null},{"first_name":"Damiano BP","last_name":null,"full_name":null},{"first_name":"End D","last_name":null,"full_name":null},{"first_name":"Giardino EC","last_name":null,"full_name":null},{"first_name":"Lu T","last_name":null,"full_name":null},{"first_name":"Markotan T","last_name":null,"full_name":null},{"first_name":"Maryanoff BE","last_name":null,"full_name":null},{"first_name":"Player MR.","last_name":null,"full_name":null},{"first_name":"Shukla U","last_name":null,"full_name":null},{"first_name":"Spurlino J","last_name":null,"full_name":null},{"first_name":"Tomczuk BE","last_name":null,"full_name":null}],"url":"https:\/\/molmedb.upol.cz\/api\/v1\/publications\/2067","landing_page":"https:\/\/molmedb.upol.cz\/publication\/2067","created_at":"2023-06-23T10:10:01.000000Z","updated_at":null}}