{"data":{"id":1998,"citation":"Liu L, Siegmund A, Xi N, Kaplan-Lefko P, Rex K, Chen A, Lin J, Moriguchi J, Berry L, Huang L, Teffera Y, Yang Y, Zhang Y, Bellon SF, Lee M, Shimanovich R, Bak A, Dominguez C, Norman MH, Harmange JC, Dussault I, Kim TS.: Discovery of a potent, selective, and orally bioavailable c-Met inhibitor: 1-(2-hydroxy-2-methylpropyl)-N-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (AMG 458). J Med Chem, Volume 51 (13), 2008","title":"Discovery of a potent, selective, and orally bioavailable c-Met inhibitor: 1-(2-hydroxy-2-methylpropyl)-N-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (AMG 458).","doi":"10.1021\/jm800401t","doi_url":"https:\/\/doi.org\/10.1021\/jm800401t","pmid":"18553959","pmid_url":"https:\/\/pubmed.ncbi.nlm.nih.gov\/18553959\/","year":2008,"journal":"J Med Chem","volume":"51","issue":"13","page":"3688-3691","authors":[{"first_name":"Bak A","last_name":null,"full_name":null},{"first_name":"Bellon SF","last_name":null,"full_name":null},{"first_name":"Berry L","last_name":null,"full_name":null},{"first_name":"Chen A","last_name":null,"full_name":null},{"first_name":"Dominguez C","last_name":null,"full_name":null},{"first_name":"Dussault I","last_name":null,"full_name":null},{"first_name":"Harmange JC","last_name":null,"full_name":null},{"first_name":"Huang L","last_name":null,"full_name":null},{"first_name":"Kaplan-Lefko P","last_name":null,"full_name":null},{"first_name":"Kim TS.","last_name":null,"full_name":null},{"first_name":"Lee M","last_name":null,"full_name":null},{"first_name":"Lin J","last_name":null,"full_name":null},{"first_name":"Liu L","last_name":null,"full_name":null},{"first_name":"Moriguchi J","last_name":null,"full_name":null},{"first_name":"Norman MH","last_name":null,"full_name":null},{"first_name":"Rex K","last_name":null,"full_name":null},{"first_name":"Shimanovich R","last_name":null,"full_name":null},{"first_name":"Siegmund A","last_name":null,"full_name":null},{"first_name":"Teffera Y","last_name":null,"full_name":null},{"first_name":"Xi N","last_name":null,"full_name":null},{"first_name":"Yang Y","last_name":null,"full_name":null},{"first_name":"Zhang Y","last_name":null,"full_name":null}],"url":"https:\/\/molmedb.upol.cz\/api\/v1\/publications\/1998","landing_page":"https:\/\/molmedb.upol.cz\/publication\/1998","created_at":"2023-06-23T10:09:47.000000Z","updated_at":null}}