{"data":{"id":1962,"citation":"Pinto DJ, Orwat MJ, Koch S, Rossi KA, Alexander RS, Smallwood A, Wong PC, Rendina AR, Luettgen JM, Knabb RM, He K, Xin B, Wexler RR, Lam PY.: Discovery of 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide (apixaban, BMS-562247), a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa. J Med Chem, Volume 50 (22), 2007","title":"Discovery of 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide (apixaban, BMS-562247), a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa.","doi":"10.1021\/jm070245n","doi_url":"https:\/\/doi.org\/10.1021\/jm070245n","pmid":"17914785","pmid_url":"https:\/\/pubmed.ncbi.nlm.nih.gov\/17914785\/","year":2007,"journal":"J Med Chem","volume":"50","issue":"22","page":"5339-5356","authors":[{"first_name":"Alexander RS","last_name":null,"full_name":null},{"first_name":"He K","last_name":null,"full_name":null},{"first_name":"Knabb RM","last_name":null,"full_name":null},{"first_name":"Koch S","last_name":null,"full_name":null},{"first_name":"Lam PY.","last_name":null,"full_name":null},{"first_name":"Luettgen JM","last_name":null,"full_name":null},{"first_name":"Orwat MJ","last_name":null,"full_name":null},{"first_name":"Pinto DJ","last_name":null,"full_name":null},{"first_name":"Rendina AR","last_name":null,"full_name":null},{"first_name":"Rossi KA","last_name":null,"full_name":null},{"first_name":"Smallwood A","last_name":null,"full_name":null},{"first_name":"Wexler RR","last_name":null,"full_name":null},{"first_name":"Wong PC","last_name":null,"full_name":null},{"first_name":"Xin B","last_name":null,"full_name":null}],"url":"https:\/\/molmedb.upol.cz\/api\/v1\/publications\/1962","landing_page":"https:\/\/molmedb.upol.cz\/publication\/1962","created_at":"2023-06-23T10:09:40.000000Z","updated_at":null}}