{"data":{"id":1545,"citation":"Hadida S, Van Goor F, Zhou J, Arumugam V, McCartney J, Hazlewood A, Decker C, Negulescu P, Grootenhuis PD.: Discovery of N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (VX-770, ivacaftor), a potent and orally bioavailable CFTR potentiator. J Med Chem, Volume 57 (23), 2014","title":"Discovery of N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (VX-770, ivacaftor), a potent and orally bioavailable CFTR potentiator.","doi":"10.1021\/jm5012808","doi_url":"https:\/\/doi.org\/10.1021\/jm5012808","pmid":"25441013","pmid_url":"https:\/\/pubmed.ncbi.nlm.nih.gov\/25441013\/","year":2014,"journal":"J Med Chem","volume":"57","issue":"23","page":"9776-9795","authors":[{"first_name":"Arumugam V","last_name":null,"full_name":null},{"first_name":"Decker C","last_name":null,"full_name":null},{"first_name":"Grootenhuis PD.","last_name":null,"full_name":null},{"first_name":"Hadida S","last_name":null,"full_name":null},{"first_name":"Hazlewood A","last_name":null,"full_name":null},{"first_name":"McCartney J","last_name":null,"full_name":null},{"first_name":"Negulescu P","last_name":null,"full_name":null},{"first_name":"Van Goor F","last_name":null,"full_name":null},{"first_name":"Zhou J","last_name":null,"full_name":null}],"url":"https:\/\/molmedb.upol.cz\/api\/v1\/publications\/1545","landing_page":"https:\/\/molmedb.upol.cz\/publication\/1545","created_at":"2021-01-20T13:49:29.000000Z","updated_at":null}}