{"data":{"id":90,"name":"Liposomal Release\/Influx Assay","abbreviation":"Liposomes","description":"<p>The Liposomal Release\/Influx Assay is an <em>in vitro<\/em> technique that employs liposomes as biomimetic carriers to evaluate drug permeability and membrane interactions. In this assay, compounds are either encapsulated within liposomes and monitored for release into the surrounding medium, or applied externally to assess influx into liposomal vesicles. Liposomes can be prepared with defined phospholipid compositions, enabling the simulation of different biological barriers, such as intestinal or blood\u2013brain membranes. Permeability is quantified by tracking drug concentrations using spectroscopic or chromatographic methods. The approach offers high flexibility and allows differentiation between passive diffusion, membrane destabilization, and active release triggered by pH, enzymes, or surfactants. While less complex than cell-based models, liposomal assays provide valuable mechanistic insights into drug\u2013membrane interactions.<\/p><p><br><\/p>","categories":[{"id":168,"title":"Permeability","breadcrumb":[{"id":4,"title":"Experimental"},{"id":168,"title":"Permeability"}]}],"url":"https:\/\/molmedb.upol.cz\/api\/v1\/methods\/90","landing_page":"https:\/\/molmedb.upol.cz\/method\/90","created_at":"2023-08-04T11:57:31.000000Z","updated_at":"2026-07-02T12:21:30.000000Z"}}