{"data":{"id":57,"name":"CPapp","abbreviation":"CPapp","description":"<p style=\"text-align: justify;\">Cppap is a mechanistic model to predict apparent passive permeability (Papp) across Caco-2 and MDCK monolayers. The approach describes permeability as the sum of three parallel pathways\u2014cytosolic, paracellular, and lateral\u2014each consisting of serial resistances such as unstirred water layers (UWL), membrane bilayers, cytosol, and filter pores (as is illustrated in the figure). The model is grounded in the solubility\u2013diffusion concept and accounts for ionization equilibria and pH partitioning. For 151 chemicals at pH 7.4, predictions showed good agreement with experimental data (R\u00b2 = 0.77, RMSE = 0.48). Independent validation against black lipid membrane (BLM) experiments yielded accurate intrinsic membrane permeabilities (R\u00b2 = 0.91). The model highlights that UWL and paracellular routes often dominate over intrinsic membrane resistance.<\/p><p style=\"text-align: justify;\"><img src=\"https:\/\/admin.molmedb.upol.cz\/storage\/uploads\/methods\/attachments\/obk5lL9Jkwm1GVVC3Kt2JUVkyBP6j7WUOeORabnh.png\" data-id=\"uploads\/methods\/attachments\/obk5lL9Jkwm1GVVC3Kt2JUVkyBP6j7WUOeORabnh.png\"><\/p><p style=\"text-align: justify;\"><\/p><p style=\"text-align: justify;\">source of image: <a href=\"https:\/\/doi.org\/10.1371\/journal.pone.0190319\" target=\"_blank\">10.1371\/journal.pone.0190319<\/a><\/p>","categories":[{"id":9,"title":"Mechanistic","breadcrumb":[{"id":5,"title":"Computed"},{"id":9,"title":"Mechanistic"}]}],"url":"https:\/\/molmedb.upol.cz\/api\/v1\/methods\/57","landing_page":"https:\/\/molmedb.upol.cz\/method\/57","created_at":"2020-01-17T14:00:18.000000Z","updated_at":"2026-06-29T13:23:49.000000Z"}}