{"data":{"id":50,"name":"\u00a0Franz Diffusion Cell","abbreviation":"Franz_cell","description":"

The Franz diffusion cell is a widely used in vitro<\/em> and ex vivo<\/em> model for evaluating the permeability of compounds across membranes. Originally developed for skin permeation studies, it is also applied to investigate transport across intestinal and other epithelial barriers.<\/p>

The system consists of two chambers separated by a membrane. The donor compartment<\/strong> contains the test formulation, while the receptor compartment<\/strong> is filled with a receptor medium. During the experiment, compounds diffuse through the membrane from the donor to the receptor side under a concentration gradient. The receptor medium is continuously stirred and maintained at a controlled temperature, and samples are collected at defined time points for analysis, typically by HPLC or UV spectroscopy.<\/p>

Franz diffusion cells are commonly used to evaluate drug release, membrane permeability, formulation performance, and absorption of pharmaceutical compounds. The method provides a simple, reproducible, and versatile approach for permeability studies, although reliable results depend on careful control of experimental conditions, including membrane integrity, sink conditions, temperature, and receptor medium composition.<\/p>



\u00a0Source of image: 10.3390\/pharmaceutics15041146<\/a><\/p>","categories":[{"id":168,"title":"Permeability","breadcrumb":[{"id":4,"title":"Experimental"},{"id":168,"title":"Permeability"}]}],"url":"https:\/\/molmedb.upol.cz\/api\/v1\/methods\/50","landing_page":"https:\/\/molmedb.upol.cz\/method\/50","created_at":"2019-07-23T16:19:32.000000Z","updated_at":"2026-07-02T09:30:05.000000Z"}}