{"data":{"id":47,"name":"pH-Metric Titration","abbreviation":"pH_Titration","description":"<p>The pH-metric titration method determines octanol\u2013water partition coefficients (logP) by comparing sequential titrations of a weak acid before and after adding octanol. A first aqueous titration establishes the true pKa from the mid-buffer inflection point. After octanol is introduced, a second back-titration produces shifted inflection points reflecting partitioning of protonated or deprotonated species into the organic phase. The difference between apparent and true pKa values, combined with the octanol\u2013water volume ratio, yields log P through derived equations for mono- and multiprotic acids. Difference plots (n\u0304H vs. \u2013log[H\u207a]) enhance pKa detection and reveal ion-pair partitioning.<\/p>","categories":[{"id":7,"title":"Partitioning","breadcrumb":[{"id":4,"title":"Experimental"},{"id":7,"title":"Partitioning"}]}],"url":"https:\/\/molmedb.upol.cz\/api\/v1\/methods\/47","landing_page":"https:\/\/molmedb.upol.cz\/method\/47","created_at":"2019-05-07T11:16:36.000000Z","updated_at":"2026-07-02T09:38:00.000000Z"}}