The Stockholm lipids (Slipids) force field is widely applied in molecular dynamics simulations of lipid bilayers, offering refined all-atom parameters for phosphatidylcholine and related lipids. Developed by J\u00e4mbeck and Lyubartsev, Slipids is based on high-level ab initio calculations and validated against experimental data such as NMR order parameters and X-ray scattering, ensuring accurate reproduction of bilayer structure and dynamics. For biomolecular simulations, Slipids is frequently combined with the AMBER force fields. In particular, AMBER99SB and its successor ff14SB, which improve protein backbone and side chain dihedral parameters, are often paired with Slipids for modeling proteins, water, and solutes. This hybrid approach provides a robust framework to study lipid\u2013protein interactions, membrane biophysics, and dye or drug partitioning in complex membrane environments.<\/p>
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<\/p>","categories":[{"id":11,"title":"Atomistic MD","breadcrumb":[{"id":6,"title":"Simulated"},{"id":11,"title":"Atomistic MD"}]}],"url":"https:\/\/molmedb.upol.cz\/api\/v1\/methods\/46","landing_page":"https:\/\/molmedb.upol.cz\/method\/46","created_at":"2019-05-07T09:56:50.000000Z","updated_at":"2026-07-09T06:28:53.000000Z"}}