1-stearoyl-2-oleoyl-phosphatidylcholine (SOPC) is a mixed-chain phosphatidylcholine (18:0\/18:1 PC) lipid widely used in model bilayers. SOPC membranes are fluid at physiological temperature and allow moderate permeability, with water diffusion and solute partitioning influenced by incorporation of cholesterol or unsaturated lipids, which can reduce permeability and increase.<\/p>
1-stearoyl-2-oleoyl-phosphatidylserine (SOPS) is the phosphatidylserine analog with the same acyl chains but a negatively charged serine head group. Including SOPS in bilayers introduces negative surface charge and electrostatic interactions, affecting ion partitioning and interaction with charged solutes or proteins. PS lipids (like SOPS) tend to reside in the inner leaflet of biological membranes and play important roles in signaling and membrane.<\/p>
When blended, SOPC:SOPS mixtures combine fluid barrier properties with electrostatic modulation, useful in studies of charged drug permeation.<\/p>
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