{"data":{"id":59,"name":"dipalmitoylphosphatidylcholine : dioleoylphosphatidylcholine : cholesterol membrane","abbreviation":"DPPC_DOPC_CHOL","description":"

Ternary membranes combining dipalmitoylphosphatidylcholine (DPPC), dioleoylphosphatidylcholine (DOPC), and cholesterol (CHOL) are widely used to study lipid domain formation, phase behavior, and permeability. At physiological temperature, DPPC tends to lie in a gel or ordered state (due to saturated acyl chains), while DOPC remains fluid (due to unsaturation). Cholesterol partitions preferentially into DPPC-rich regions and stabilizes liquid-ordered (Lo) domains, promoting coexistence of Lo and liquid-disordered (Ld) phases in mixed bilayers.<\/a><\/p>

This heterogeneity affects permeability: solutes permeate more slowly through ordered, cholesterol-rich domains than through disordered, fluid regions. The presence of cholesterol condenses lipid packing, reduces free volume, and lowers diffusivity of small molecules, thereby decreasing overall permeability relative to pure DOPC membranes. Such DPPC:DOPC:CHOL membranes serve as biophysically relevant models of cell membranes, enabling investigation of lipid\u2013solute interactions, domain-dependent transport, and membrane barrier modulation.<\/p>


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