{"data":{"id":53,"name":"1,2-diphytanoyl-sn-glycero-3-phosphocholine","abbreviation":"DPhPC","description":"<p style=\"text-align: justify;\">1,2-diphytanoyl-sn-glycero-3-phosphocholine (DPhPC) is a synthetic phosphocholine lipid bearing phytanyl branched acyl chains, which confer exceptional chemical and thermal stability and prevent gel\u2013fluid transition within a broad temperature range. Because of these properties, DPhPC bilayers serve as robust model membranes in permeability and electrophysiological studies. In planar DPhPC bilayers, passive permeability to neutral solutes and water is measurable but small, while ion permeation is extremely low and often occurs via defect or deformation-driven mechanisms rather than classical solubility\u2013diffusion models<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0005273616301316?utm_source=chatgpt.com\">.<\/a> Cholesterol and sphingomyelin reportedly exert minimal influence on DPhPC permeability, suggesting the intrinsic lipid structure governs barrier behavior. DPhPC membranes thus provide a controlled, reproducible barrier model, especially useful for separating passive diffusion from transporter effects.<\/p>","categories":[{"id":62,"title":"Model","breadcrumb":[{"id":71,"title":"Brain"},{"id":62,"title":"Model"}]}],"url":"https:\/\/molmedb.upol.cz\/api\/v1\/membranes\/53","landing_page":"https:\/\/molmedb.upol.cz\/membrane\/53","created_at":"2020-11-23T14:17:30.000000Z","updated_at":"2026-06-28T17:45:22.000000Z"}}