{"data":{"id":47,"name":"CALU-3","abbreviation":"CALU-3","description":"<p>Calu-3 is a human bronchial submucosal gland carcinoma cell line widely used as an <em>in vitro<\/em> airway epithelial model. When grown at an air\u2013liquid interface, Calu-3 cells form polarized monolayers with tight junctions, high transepithelial resistance, and mucus secretion, resembling the conducting airway epithelium. They express functional ion transport systems, including CFTR-mediated chloride and bicarbonate secretion, and serve as a model of submucosal gland serous cell activity.<\/p><p>Calu-3 cells also express uptake and efflux transporters relevant to pulmonary drug disposition, including P-glycoprotein and BCRP. Their secretory activity, barrier properties, and inflammatory responses make them valuable for studying respiratory drug delivery, infection, airway inflammation, and injury induced by oxygen or mechanical ventilation.<\/p><p>Cellosaurus: <a href=\"https:\/\/www.cellosaurus.org\/CVCL_0609\" target=\"_blank\">https:\/\/www.cellosaurus.org\/CVCL_0609<\/a><\/p><p><\/p>","categories":[{"id":154,"title":"Experimental","breadcrumb":[{"id":152,"title":"Cell"},{"id":154,"title":"Experimental"}]}],"url":"https:\/\/molmedb.upol.cz\/api\/v1\/membranes\/47","landing_page":"https:\/\/molmedb.upol.cz\/membrane\/47","created_at":"2020-11-04T12:48:10.000000Z","updated_at":"2026-06-29T08:10:55.000000Z"}}