1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC, 16:0\/18:1 PC) and 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine (POPE, 16:0\/18:1 PE) are widely used lipids in model bilayers. POPC bilayers are fluid, relatively disordered, and highly hydrated, making them a standard \u201cbenchmark\u201d membrane for permeability and partitioning studies. In contrast, POPE bilayers pack more tightly due to smaller ethanolamine headgroups and intermolecular hydrogen bonding, yielding reduced surface hydration, greater thickness, and lower passive permeability to small solutes.<\/p>
In biological membranes, PC is enriched in the outer leaflet, while PE is more abundant in the inner leaflet, where it contributes to curvature and dynamic remodeling.<\/p>
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