{"data":{"id":38,"name":"Lecithin in n-Dodecane","abbreviation":"Lecithin","description":"<p>Artificial membranes composed of lecithin dissolved in <em>n<\/em>-dodecane are widely used in passive permeability assays, such as the Parallel Artificial Membrane Permeability Assay (PAMPA). Lecithin, a natural phospholipid mixture, forms a stable bilayer-like barrier when spread in an <em>n<\/em>-dodecane matrix. This setup mimics the hydrophobic environment of biological membranes while remaining free of active transport processes.<\/p><p>The system enables measurement of passive diffusion driven by concentration gradients, allowing efficient, high-throughput screening of drug candidates. Permeability values obtained correlate with intestinal absorption and help distinguish compounds absorbed by transcellular diffusion from those relying on other uptake mechanisms.<\/p>","categories":[{"id":154,"title":"Experimental","breadcrumb":[{"id":152,"title":"Cell"},{"id":154,"title":"Experimental"}]}],"url":"https:\/\/molmedb.upol.cz\/api\/v1\/membranes\/38","landing_page":"https:\/\/molmedb.upol.cz\/membrane\/38","created_at":"2019-08-21T09:32:20.000000Z","updated_at":"2026-06-29T12:39:57.000000Z"}}