{"data":{"id":31,"name":"Stratum Corneum\u00a0","abbreviation":"SC","description":"

The stratum corneum\u00a0 (Latin for 'horny layer') is the outermost epidermal layer and the principal barrier of the skin. It is organized as a \u201cbrick-and-mortar\u201d structure in which keratin-rich corneocytes are embedded in a continuous, multilamellar lipid matrix that restricts both water loss and entry of exogenous chemicals. This lipid matrix\u2014dominated by ceramides, cholesterol, and long-chain fatty acids\u2014forms highly ordered lamellar bilayers, which are essential for low permeability to hydrophilic and hydrophobic molecules. The barrier function arises from coordinated lipid synthesis, lamellar body secretion, and enzymatic processing at the stratum granulosum\u2013SC interface, producing the extracellular lipids that build the permeability barrier. The SC also responds dynamically to environmental humidity: decreased hydration reduces water permeability, whereas increased hydration enhances chemical permeability, demonstrating that the SC functions as a responsive barrier membrane. Together, these structural and biochemical features make the SC a robust, adaptable barrier central to cutaneous defense.<\/p>

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Lamellar and lateral organization in human stratum corneum<\/p>

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Image source: 10.1194\/jlr.P030338<\/u><\/a><\/p>","categories":[{"id":70,"title":"Experimental","breadcrumb":[{"id":61,"title":"Skin"},{"id":70,"title":"Experimental"}]}],"url":"https:\/\/molmedb.upol.cz\/api\/v1\/membranes\/31","landing_page":"https:\/\/molmedb.upol.cz\/membrane\/31","created_at":"2019-07-19T07:23:46.000000Z","updated_at":"2026-06-28T18:07:52.000000Z"}}