{"data":{"id":28,"name":"Sphingomyelin : Cholesterol Membranes","abbreviation":"SM_CHOL","description":"<p>Binary mixtures of sphingomyelin (SM) and cholesterol (Chol) in a 2:1 molar ratio form highly ordered lipid bilayers that mimic the <em>liquid-ordered (Lo)<\/em> phase found in mammalian plasma membranes. This composition produces condensed, thick bilayers with reduced lateral diffusion, high acyl chain order, and limited free volume. Such membranes are widely used as models of cholesterol- and sphingolipid-rich \u201craft\u201d domains, which are implicated in signaling, protein sorting, and drug\u2013membrane interactions.<\/p><p>Compared with phosphatidylcholine membranes, SM:Chol bilayers display lower permeability to small solutes and ions, reflecting their tighter packing and increased thickness. These physicochemical properties make them valuable in experimental and computational studies of membrane organization, probe partitioning, and barrier function<\/p><p><\/p>","categories":[{"id":69,"title":"Model","breadcrumb":[{"id":61,"title":"Skin"},{"id":69,"title":"Model"}]}],"url":"https:\/\/molmedb.upol.cz\/api\/v1\/membranes\/28","landing_page":"https:\/\/molmedb.upol.cz\/membrane\/28","created_at":"2019-05-07T09:30:30.000000Z","updated_at":"2026-06-28T18:14:01.000000Z"}}