Mixture of phospholipids dissolved in alkanes, such as n-dodecane or hexadecane, are widely used to form artificial membranes in parallel artificial membrane permeability assays (PAMPA). In these hybrid systems, the alkane provides a hydrophobic solvent phase embedding phospholipid tails, while polar headgroups orient toward aqueous interfaces. This arrangement mimics the hydrocarbon core of biological bilayers, enabling measurement of passive diffusion.<\/p>
Such PL-A membranes reproduce key aspects of transcellular diffusion, while remaining structurally simple and high-throughput compared with cell-based models. They correlate well with human intestinal absorption for passively transported drugs, though they do not account for active transport or efflux. These systems are therefore valuable for probing hydrocarbon core contributions to permeability.<\/p>
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