{"data":{"id":23,"name":"GIT-0","abbreviation":"GIT-0","description":"<p style=\"text-align: justify;\">GIT-0 by pION Inc. is a membrane used with PAMPA method as an\u00a0<em>in vitro<\/em>\u00a0model of passive, transcellular gastrointestinal permeability. The gastrointestinal tract (GIT) has a pH range from pH 1 to 8.\u00a0 Since the pH of the blood is 7.4, there exists a pH gradient between the GIT and the plasma that can affect the transport of ionizable molecules. There are three available models of GIT-0: with pH of 5.0, 6.2, and 7.4 in the donor compartment. To model transport conditions in the blood, the acceptor contains a scavenger binding molecule that helps to keep the free concentration of the API close to zero. Additionally, the GIT-0 phospholipid is used for the assay that mimics the composition of brush border membranes.<\/p><p style=\"text-align: justify;\"><\/p>","categories":[{"id":72,"title":"Model","breadcrumb":[{"id":59,"title":"Intestine"},{"id":72,"title":"Model"}]}],"url":"https:\/\/molmedb.upol.cz\/api\/v1\/membranes\/23","landing_page":"https:\/\/molmedb.upol.cz\/membrane\/23","created_at":"2019-01-09T14:56:45.000000Z","updated_at":"2026-06-29T07:20:37.000000Z"}}